人员介绍

施福东MD / PhD京津神经免疫中心
个人概括

1966年生,瑞典Karolinska学院神经病学博士,主任医师,擅长神经免疫和炎性疾病,包括多发性硬化,视神经脊髓炎,重症肌无力等疾病的诊断和治疗。

施福东分别在哈尔滨医科大学,北京协和医院,瑞典Karolinska学院,美国Scripps研究院,美国St. Joseph医院Barrow神经病学研究所先后完成临床和科研训练。 “长江学者”特聘教授、国家“千人计划”,国家重大科学研究计划项目(973)首席科学家。学术兼职包括泛亚多发性硬化治疗和研究委员会(PACTRIMS)委员,中华医学会神经病学分会委员会常务委员,天津市医学会神经病学分会主任委员。获得首届“中国卒中创新研究奖”、第三届“中国卒中奖”、“中国杰出神经内科医师”称号。获得美国发明专利1项。

施福东长期致力于研究天然免疫在神经疾病中的作用,并探索新的免疫治疗策略。近年发现了脑内炎症和免疫反应的特异性,完善了神经免疫疾病的实验室辅助诊断,寻找出适合我国国情的视神经脊髓炎的治疗方案,对脑血管病的免疫机制和免疫干预进行了开创性的探索。在Nat Immunol, PNAS, Nat Rev Immunol, J Exp Med, Ann Neurol, Neurology, JAMA Neurology, Circulation, Nat Rev Neurol, Nat Neurosci, Immunity等杂志上发表文章165篇,参编专著11部。

代表性论文
Original articles
  1. Zhang C, Tian DC, Yang CS, Han B, Wang J, Yang L, Shi FD. Safety and Efficacy of Bortezomib in Patients With Highly Relapsing Neuromyelitis Optica Spectrum Disorder. JAMA Neurol. 2017;74(8):1010-1012. 影响因子:10.029.
  2. Jiang W, Li D, Han R, Zhang C, Jin WN, Wood K, Liu Q, Shi FD, Hao J. Acetylcholine-producing NK cells attenuate CNS inflammation via modulation of infiltrating monocytes/macrophages. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6202-E6211. 影响因子:9.423.
  3. Liu Q, Jin WN, Liu Y, Shi K, Sun H, Zhang F, Zhang C, Gonzales R, Sheth KN, La Cava A, Shi FD. Brain ischemia suppresses immunity in the periphery and brain via different neurogenic innervations. Immunity. 2017 46:474-487. 影响因子:24.082. 引用次数:6.  Immunity社论专题评述: Linda Quatrini1 and Sophie Ugolini1, Disarming the Killers: Brain Strikes on NK Cells. DOI: http://dx.doi.org/10.1016/j.immuni.2017.03.001.
  4. Li M, Li Z, Yao Y, Jin WN, Wood K, Liu Q, Shi FD, Hao J. Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity. Proc Natl Acad Sci U S A. 2017;114: E396-E405. 影响因子:9.423. 引用次数:5.  Proc Natl Acad Sci U S A社论专题评述: Meaghan Roy-O’Reilly and Louise D. McCullough, Astrocytes fuel the fire of lymphocyte toxicity after stroke. 2017:114,425-427.  
  5. Liu Q, Sanai N, Jin WN, La Cava A, Van Kaer L, and Shi FD. 2016. Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation. Nat Neurosci. 19:243-52. 影响因子:16.724. 引用次数:25.  Nature Neuroscience社论专题评述:Jonathan Kipnis, et al. Natural killers in the brain's nursery. 2016:19,176–177.
  6. Zhu Z, Fu Y, Tian D, Sun N, Han W, Chang G, Dong Y, Xu X, Liu Q, Huang D, Shi FD. 2015. Combination of an immune modulator fingolimod with alteplase in acute ischemic stroke. Circulation. 132:1104-12. 影响因子:17.047. 引用次数:48.
  7. Fu Y, Zhang N, Ren L, Yan Y, Sun N, Li YJ, Han W, Xue R, Liu Q, Hao J, Yu C, Shi FD. 2014. Impact of an immune modulator fingolimod on acute ischemic stroke. Proc Natl Acad Sci U S A. 111:18315-20. 影响因子:9.423. 引用次数:61.
  8. Fu Y, Hao J, Zhang N, Ren L, Sun N, Li YJ, Yan Y, Huang D, Yu C, Shi FD. 2014. Fingolimod for the Treatment of Intracerebral Hemorrhage: A 2-Arm Proof-of-Concept Study. JAMA Neurol. 71:1092-101. 影响因子:8.23. 引用次数:82.  美国心脏病学学会(AHA)头版头条报道:“Stroke Rounds: An MS Drug for ICH?”;  JAMA Neurology社论专题评述:Kevin N. Sheth and Jonathan Rosand, Targeting the Immune System in Intracerebral Hemorrhage. 2014;71:1083-4.
  9. Gan Y, Liu Q, Wu W, Yin J, Tang Z, Turner G, Chen J, Wang Y, Lanrent J, Yokayama W, Shi FD. 2014. Ischemic neurons recruit NK cells that accelerate brain infarction. Proc Natl Acad Sci USA. 111:2704-9. 影响因子:9.423. 引用次数:63.
  10. Yang CS, Yang L, Li T, Zhang DQ, Jin WN, Li MS, Su N, Zhang NN, Shao ZH, Yu CS, and Shi FD. 2013. Responsiveness to reduced dosage of rituximab in Chinese neuromyelitis optica patients. Neurology. 81:710-3. 影响因子:8.166. 引用次数:46.
  11. Hao JW, Campagnolo DI, Liu R, Piao WH, Shi S, Hu B, Xiang R, Zhou Q, Vollmer TL, Van Kaer L, La Cava A, and Shi FD. 2011. Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation. Ann Neurol. 69:721-34. 影响因子:9.638. 引用次数:52.
  12. Hao JW, Liu R, Piao WH, Zhou Q, Vollmer TL, Xiang R, La Cava A, Campagnolo DI, Van Kaer L, and Shi FD. 2010. CNS-resident NK cells suppress Th17 responses and CNS autoimmune pathology. J Exp Med. 207:1907-1921. 影响因子:11.24. 引用次数:146.  封面文章和Nature专题报道“Killer cells help”.
  13. Shi FD, Flodstrom M, Balasa B, Kim SH, Van Gunst K, Strominger JL, Wilson SB, and Sarvetnick N. 2001. Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc Natl Acad Sci USA. 58:6777-6782. 影响因子:9.423. 引用次数:195.
  14. Shi FD, Wang H, Li H, Hong S, Tanihuchi M, Link H, Van Kaer L, and Ljunggren HG. 2000. Natural killer cells determine the outcome of B cell-mediated autoimmunity. Nat Immunol. 1:245-251. 影响因子:19.381. 引用次数:200.
代表性论文
Reviews
  1. Fu Y, Liu Q, Anrather J, Shi FD. 2015. Immune interventions in stroke. Nat Rev Neurol. 11(9):524-35. 影响因子:18.418. 引用次数:49.
  2. Shi FD, Ljunggren HG, La Cava A, Van Kaer, L. 2011. Organ-specific features of NK cells. Nat Rev Immunol. 11, 658-671. 影响因子:39.416. 引用次数: 213. 杂志10周年特别刊出.
  3. Shi FD and Jia JP. 2011. Neurology and neurological practice in China. Neurology. 77:1986-92. 影响因子:8.166. 引用次数:18.
  4. Shi FD and Van Kaer L. 2006. Reciprocal regulation between NK cells and autoreactive T cells. Nat Rev Immunol. 6:751-760. 影响因子:39.416. 引用次数:118.
  5. La Cava A, Van Kaer L, and Shi FD. 2006. CD4+CD25+ regulatory T cells and NKT cells: regulators regulating regulators. Trends Immunol. 27: 322-327. 影响因子:11.433. 引用次数:207.
  6. Shi FD, Ljunggren .G, and Sarvetnick N. 2001. Innate immunity and autoimmunity: from-self protection to self-aggression. Trends Immunol.  22:97-101. 影响因子:11.433. 引用次数:147.   Trends Immunol社论专题评述:  De la Salle H. Autoimmunity mediated by innate immune effector cells. 2001: 22:300-1.